| 79400002 | 2/27/2022 | 1:00 PM | Notr / NDCL Gym | Our Lady of the Lake (Lovelady) | 24 | Gesu (Hanna) | 23 |
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| 79400001 | 2/27/2022 | 2:00 PM | Notr / NDCL Gym | St. Agatha-St. Aloysius (Jones) | 25 | St. Benedict (Anderson) | 17 |
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| 79400003 | 3/5/2022 | 9:00 AM | Cent / CPL Fieldhouse | Our Lady of the Lake (Lovelady) | 20 | St. Francis of Assisi (Tibaldi) | 34 |
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| 79400004 | 3/5/2022 | 4:30 PM | Gilm / Gilmour Academy Main Gym | St. Agatha-St. Aloysius (Jones) | 18 | Corpus Christi Academy-Lyndhurst (Dean) | 24 |
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| 79400005 | 3/6/2022 | 7:00 PM | Ursuline College-Pepper Pike / Siedman Gymnasium | Corpus Christi Academy-Lyndhurst (Dean) | 13 | St. Francis of Assisi (Tibaldi) | 24 |
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